Biomarkers: Blood Testing For Mood Disorders
There are currently no objective clinical laboratory blood tests for mood disorders. The current reliance on patient self-report of symptom severity and on the clinicians’ impression is a rate limiting step in effective treatment and new drug development.
Investigators from Indiana propose, and provide proof of principle for, an approach to help identify blood biomarkers for mood state. They measured whole-genome gene expression differences in blood samples from subjects with bipolar disorder that had low mood vs. those that had high mood at the time of the blood draw, and separately, changes…