Meta-Analyses Get Lots Of Attention, Without Noting That Approaches Affect Outcomes
Depending on the analysis strategy used, estimating treatment outcomes in meta-analyses may differ and may result in major alterations in the conclusions derived from the analysis, according to a study in JAMA which could easily apply to all fields.
Meta-analyses of randomized clinical trials are generally considered to provide among the best evidence of efficacy of medical interventions. They should be conducted as part of a systematic review, a scientifically rigorous approach that identifies, selects, and appraises all relevant studies. Which trials to combine in a metaanalysis…