Genetics & Molecular Biology
DNA testing carried out by University of Leicester geneticists and funded by The Wellcome Trust has thrown new light on the ancestry of one of the USA’s most revered figures, the third President, Thomas Jefferson.
Almost 10 years ago, the University of Leicester team, led by Professor Mark Jobling, together with international collaborators, showed that Thomas Jefferson had fathered at least one of the sons of Sally Hemings, a slave of Jefferson’s.
The work was done using the Y chromosome, a male-specific part of our DNA that passes down from father to son. Jefferson carried a very unusual Y…
Direct detection of base sequence in duplex nucleic acid has long been an unfulfilled objective. Ingeneus Research will publish "Heteropolymeric Triplex-Based Genomic Assay® to Detect Pathogens or Single-Nucleotide Polymorphisms in Human Genomic Samples" in the March 21st issue of the international, peer-reviewed, open access, online journal, PLoS ONE. In the article they present a wealth of data relating to the assay of pathogens in samples also containing human genomic duplex DNA and to the assay of SNPs present in human genomic samples. The assays are carried out homogeneously and in…
Could you survive a day like Jack Bauer has on the Fox television show "24?" Maybe not, and it might not be just because you lack counter-terrorism training.
People are known to differ markedly in their response to sleep deprivation, but the biological underpinnings of these differences have remained difficult to identify. Researchers have now found that a genetic difference in a so-called clock gene, PERIOD3, makes some people particularly sensitive to the effects of sleep deprivation. The findings, reported by Antoine Viola, Derk-Jan Dijk, and colleagues at the University of Surrey's Sleep…
CORRECTION: Charles Margulis -- who works with the so-called Center for Food Safety, an organic food lobbying group -- has called my attention to the fact that 200 people were made seriously ill (rather than dead) from eating manure-contaminated fresh spinach last fall. Only three people actually died. My apologies for the unintentional error.
"Proper composting" of manure is supposed to kill off the trillions of bacteria that are naturally present in the fresh stuff (otherwise known as "poop" in the language used by my son). But something went wrong at some point…
Students of the evolution of social behavior got a big boost with the publication of the newly sequenced honeybee genome in October 2006. The honeybee (Apis mellifera) belongs to the rarified cadre of insects that pool resources, divide tasks, and communicate with each other in highly structured colonies. Understanding how this advanced state of organization evolved from a solitary lifestyle has been an enduring question in biology.
A honeybee gene originally used in egg production has become an important behavioral modulator and a timekeeper of social life. Credit: Image: Siri-Christine…
At unprecedented levels of difficulty involving highly biodiverse and continent-sized landscapes, scientists have successfully tested their ability to identify and DNA "barcode" entire assemblages of species -- the prelude to a genetic portrait of all animal life on Earth.
Revealing their results in the UK journal Molecular Ecology Notes, they report having assembled a genetic portrait of birdlife in the U.S. and Canada, and announce the startling discovery of 15 new genetically distinct species, nearly indistinguishable to human eyes and ears and consequently overlooked in centuries of bird…
A University of Queensland microbiologist is part of an international team that has identified a bacterial gene that may affect climate and weather.
Dr Phil Bond, from UQ's Advanced Wastewater Management Centre, and his former colleagues at the University of East Anglia in England, have found how a particular type of marine bacteria – Marinomonas – generates a compound that is a key component in global sulfur and carbon cycles.
“Marine algae can produce large amounts of a compound (dimethylsulfoniopropionate or DMSP) that when broken down by bacteria produces dimethyl sulfide (…
Scientific studies of why foods such as Brussels sprouts and stout beer are horribly bitter-tasting to some people but palatable to others are shedding light on a number of questions, from the mechanisms of natural selection to understanding how our genes affect our dietary habits.
Dr. Stephen Wooding, a population geneticist at UT Southwestern Medical Center in Dallas, studies how slight variations in genes give rise to variations in traits among a given human population.
Part of Dr. Wooding's research focuses on variations in the genes responsible for bitter-taste receptors, tiny…
Blurring boundaries High up on the bluffs overlooking the Pacific Ocean in southern California, strange animals scurry about in their cages. They eat, drink, copulate and occasionally try to run away from human hands that enter their confined quarters. If you didn't know better, you would think they were ordinary mice. But these particular animals contain a hidden component not present in their naturally conceived cousins. Inside their brains are living human neurons that help them to see, hear and think.
Fred Gage, a biologist at the Salk Institute, has created these part-human animals to…
The Allen Brain Atlas, a genome-wide map of the mouse brain on the Internet, has been hailed as “Google of the brain.” The atlas now has a companion or the brain’s working molecules, a sort of pop-up book of the proteins, or proteome map, that those genes express.
The protein map is “the first to apply quantitative proteomics to imaging,” said Richard D. Smith, Battelle Fellow at the Department of Energy’s Pacific Northwest National Laboratory, who led the mapping effort with Desmond Smith of UCLA’s David Geffen School of Medicine.
Caption: Abundance profiles of four different proteins…