Social Sciences
CAMBRIDGE, Mass., April 6, 2009 – AVEO Pharmaceuticals, Inc., a biopharmaceutical company leveraging breakthrough discoveries in cancer biology to discover, develop and commercialize targeted oncology therapies, today announced findings from its novel human-in-mouse (HIM) cancer model system, in which AVEO successfully created invasive human tumors from primary human breast tissue that develop over time in mice and mimic human tumor behaviors and response. The findings were published this week in the Early Edition of the Proceedings of the National Academy of Sciences.
More than 95 percent…
Young adults with a genetic variant that raises their risk of developing Alzheimer's Disease show changes in their brain activity decades before any symptoms might arise, according to a new brain imaging study by scientists from the University of Oxford and Imperial College London. The results may support the idea that the brain's memory function may gradually wear itself out in those who go on to develop Alzheimer's.
The research, published today in the journal Proceedings of the National Academy of Sciences, provides clues as to why certain people develop Alzheimer's Disease (AD) and it may…
HOUSTON - Brief stress management sessions prior to and immediately after surgery may have both short- and long-term benefit for men undergoing a radical prostatectomy for early-stage prostate cancer, according to research from The University of Texas M. D. Anderson Cancer Center.
The study, in the current issue of the Journal of Clinical Oncology, is the first to examine the benefits of psychosocial intervention for prostate cancer patients prior to surgery. It found that men who participated in the sessions experienced less short-term mood disturbance and better long-term quality of life,…
ST. PAUL, Minn. – A new study shows both obesity and a large belly appear to increase the risk of developing restless legs syndrome (RLS), a common sleep disorder characterized by an irresistible urge to move your legs. The research is published in the April 7, 2009, print issue of Neurology®, the medical journal of the American Academy of Neurology.
It is estimated that 5-10 percent of adults in the United States have RLS and the disorder often has a substantial impact on sleep, daily activities and quality of life.
For the study, researchers questioned 65,554 women and 23,119 men, all of…
Factors identified early in childhood could predict obesity in the teen years and beyond, and researchers continue to assess methods to prevent and treat excess weight gain and its consequences in children and teens, according to several reports published in the April issue of Archives of Pediatrics & Adolescent Medicine, one of the JAMA/Archives journals.
The issue—a theme issue on childhood obesity and diabetes—is being published in conjunction with a JAMA theme issue on diabetes. The March issue of Archives of Ophthalmology and Archives of Neurology, along with the April issues of…
Two non-pharmacological interventions—cognitive behavior therapy and supportive stress management—appear more effective than usual care for treating depression after coronary artery bypass surgery, according to a report in the April issue of Archives of General Psychiatry, one of the JAMA/Archives journals.
About one in every five patients experiences a major depressive episode following coronary artery bypass graft (CABG) surgery and at least that many develop milder forms of depression, according to background information in the article. "Depression around the time of surgery predicts…
Most males who commit suicide or need hospital care for suicide attempts during their teen or early adult years appear to have high levels of psychiatric problems at age 8, according to a report in the April issue of Archives of General Psychiatry, one of the JAMA/Archives journals. However, later suicide attempts in females are not predicted by mental health issues at this age.
"Suicide among adolescents and young adults is a major public health concern worldwide," the authors write as background information in the article. "The rates of mortality [death] by suicide have been found to be…
(SEATTLE) – The use of Avastin alone to treat a subgroup of recurrent Grade 3 brain tumors showed it was safe and effective at delaying tumor progression, according to a retrospective study of 22 patients conducted by a researcher at the Seattle Cancer Care Alliance.
The patients all had a recurrent malignant glioma known as alkylator-refractory anaplastic oligodendroglioma (AO), for which there is no existing standard therapy. Oligodendrogliomas begin in brain cells called oligodendrocytes, which provide support around nerves by building a sheath of myelin and facilitating electrical nerve…
WINSTON-SALEM, N.C. – New research at Wake Forest University School of Medicine evaluated the link between a common class of drugs used to prevent bone fractures in osteoporosis patients and the development of irregular heartbeat.
The study's findings appear in the current issue of Drug Safety, a publication of the International Society of Pharmacovigilance covering the safe and proper use of medicines.
"Some trials show there could be a potential link between the use of bisphosphonates and the development of serious heart rhythm problems, but in our study the link wasn't conclusive," said…
Scientists of the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch and Charité – University Medical School, Berlin, Germany, in collaboration with researchers from the Klinikum rechts der Isar of Technical University Munich and Christian Albrecht University, Kiel, have identified a gene variant on chromosome 11 that is associated with an increased risk of atopic dermatitis. In a large genome-wide association study the researchers scanned the genomes of more than 9600 participants from Germany, Poland and the Czech Republic. "Our findings cast new light on the pathogenesis of the…