Why does Menthol feel 'fresh'?
Scientists have identified the receptor in cells of the peripheral nervous system that is most responsible for the body's ability to sense cold.
The findings reveal one of the key mechanisms by which the body detects temperature sensation. But in so doing it also illuminates a mechanism that mediates how the body experiences intense stimuli – temperature, in this case – that can cause pain.
Menthol and TRPM8
As such, the receptor – known as menthol receptor TRPM8 -- provides a target for studying acute and chronic pain, as can result from inflammatory or nerve injury, the researchers say,…