Immunology

The Secretariat of the Joint United Nations Programme on HIV/AIDS (UNAIDS) has lost valuable ground by ignoring for years the contribution of long-term concurrent relationships to Africa's AIDS epidemic, claims says Helen Epstein, an independent consultant on public health in developing countries, ahead of World AIDS Day on British Medical Journal (www.bmj.com) today. UNAIDS may be "contributing to the mystification of AIDS in Africa by promoting a needlessly overcomplicated view of the epidemic", says Epstein.  She argues that long term, overlapping, or "concurrent" partnerships provide…

A new species of bacterium that causes leprosy has been identified through intensive genetic analysis of a pair of lethal infections, a research team reports in the December issue of the American Journal of Clinical Pathology. All cases of leprosy, an ancient disease that still maims and kills in the developing world, previously had been thought to be caused by a single species of bacterium, said lead author Xiang-Yang Han, M.D., Ph.D., associate professor in Laboratory Medicine at The University of Texas M. D. Anderson Cancer Center.  There are hundreds of thousands of new cases of…

Bacteria that can cause serious heart disease in humans are being spread by rat fleas, sparking concern that the infections could become a bigger problem in humans. Research published in the December issue of the Journal of Medical Microbiology suggests that brown rats, the biggest and most common rats in Europe, may now be carrying the bacteria. Since the early 1990s, more than 20 species of Bartonella bacteria have been discovered. They are considered to be emerging zoonotic pathogens, because they can cause serious illness in humans worldwide from heart disease to infection of the spleen…

Scientists writing in PLoS Pathogens have reported the discovery of a new species of Ebola virus, provisionally named Bundibugyo ebolavirus. The virus, which was responsible for a hemorrhagic fever outbreak in western Uganda in 2007, has been characterized by a team of researchers from the Centers for Disease Control and Prevention in Atlanta, Georgia the Uganda Virus Research Institute; the Uganda Ministry of Health; and Columbia University. Ebola virus infection in humans causes severe disease for which there is presently no vaccine or other treatment. Case fatalities range historically…

A virus that causes cold-like symptoms in humans originated in birds and may have crossed the species barrier around 200 years ago, according to an article published in the December issue of the Journal of General Virology. Scientists hope their findings will help us understand how potentially deadly viruses emerge in humans. "Human metapneumovirus may be the second most common cause of lower respiratory infection in young children. Studies have shown that by the age of five, virtually all children have been exposed to the virus and re-infections appear to be common," said Professor Dr…

Asma Elsony led the tuberculosis programme in Sudan at the same time as she took her doctoral degree under the supervision of Professor Gunnar Bjune of the Department of General Practice and Community Medicine, University of Oslo in Norway.  During her doctoral degree studies she became President of the International Union against Tuberculosis and Lung Disease as the first African and the first President from south of the globe. During her presidency the Board moved with the DOTs model to other public health lung problems – one of many other achievements. One of the problems – and this…

Developed more than 200 years ago and found in households around the world, chlorine bleach is among the most widely used disinfectants, yet scientists never have understood exactly how this familiar product actually kills bacteria.   New research from the University of Michigan  reveals key details in the process by which bleach works its antimicrobial magic. In a study published in the Nov. 14 issue of Cell, a team led by molecular biologist Ursula Jakob describes a mechanism by which hypochlorite, the active ingredient of household bleach, attacks essential bacterial proteins,…

It sounds like a science fiction movie: A killer contagion threatens the Earth, but scientists save the day with a designer drug that forces the virus to mutate itself out of existence. The killer disease? Still a fiction. The drug? It could become a reality thanks to a new study by Rice University bioengineers. The study, which is available online and slated for publication in the journal Physical Review E, offers the most comprehensive mathematical analysis to date of the mechanisms that drive evolution in viruses and bacteria. Rather than focusing solely on random genetic mutations, as…

HIV is a master of disguise, able to rapidly change its identity and hide undetected in infected cells. But now, in a long-standing collaborative research effort partially-funded by the Wellcome Trust, scientists from Oxford-based Adaptimmune Limited, in partnership with the Universities of Cardiff and Pennsylvania have engineered immune cells to act as "bionic assassins" that see through HIV's many disguises.  The findings of the study in  Nature Medicine may have important implications for developing new treatments for HIV and slowing  or even preventing  the onset of…

Montana State University scientists concerned about lethal mold infections have found a gene that regulates the mold's resistance to drugs. The gene, called srbA, allows molds to thrive during infections even when inflammation reduces its oxygen supply, said Robert Cramer, senior author of a paper published in the Nov. 7 issue of PLoS Pathogens. When the gene is removed, the mold becomes much more vulnerable to lack of oxygen and can no longer grow to cause disease. The gene is found in humans and molds, but the researchers studied it in a common mold called Aspergillus fumigatus, said Cramer…