Genetics & Molecular Biology

I usually like Nicolas Wade, but this very first sentence of a piece in this week's NY Times science section is not right: The principal rationale for the $3 billion spent to decode the human genome was that it would enable the discovery of the variant genes that predispose people to common diseases like cancer and Alzheimer’s. This is not the principal rationale for the human genome sequence. Hyping it this way again sets life scientists up for failure, just as in the War on Cancer. People are starting to ask, so where are those cures based on knowing Alzheimer's gene variants? The human…

Yeast, the essential microorganism for fermentation in the brewing of beer, converts carbohydrates into alcohol and other products that influence appearance, aroma, and taste. In a study published online today in Genome Research, researchers have identified the genomic origins of the lager yeast Saccharomyces pastorianus, which could help brewers to better control the brewing process. For thousands of years, ale-type beers have been brewed with Saccharomyces cerevisiae (brewer's or baker's yeast). In contrast, lager beer, which utilizes fermentations carried out at much lower temperature than…

The genetic code is the metabolic instructions by which the genetic information in the DNA is translated into a protein. The fact that almost all organisms use the same code is prime evidence that all life is related in its evolutionary past. The code is considered to be "conserved" and "universal". Of course, the concept of universality may be challenged by exobiology's explorations of Mars, Europa, and Titan, but the conservative nature of the genetic code, with the exception of a few Archaebacteria, has always been a cornerstone of biological science. But the reality of course is that the…

Michael Creighton's latest thriller, Next, presents all sorts of what-if scenarios for the genetic community. While most of us will not have to deal with foul-mouthed orangutans or smart-ass parrots, a recent report published in the Proceedings of the National Academy of Sciences suggests that there may be a genetic factor contributing to fear of commitment in males. As reported today by the BBC ("Commitment phobes can blame genes", Sept 2, 2008), this gene is called AVPR1A. Males with a certain allele for this gene (allele 334) have an aversion to commitment, and are less likely to have…

The hereditary disease ponto cerebellar hypoplasia (PCH) occurs when certain areas of the brain do not develop properly; this results in severe mental and physical developmental disorders. Life expectancy of those affected ranges from a few months to a few years. Scientists from Cologne and Amsterdam have discovered the mutations in human genetics which cause PCH of the types 2 and 4. “In the case of PCH, the protein complex – the so-called tRNA-Splicing-Endonuclease, is mutated. This complex in involved in the manufacture of proteins in the human body and was identified in connection with…

Together with colleagues from the Department of Dermatology and Allergy and the Center for Allergy and Environment (ZAUM) of the Technische Universität München, scientists at the Helmholtz Zentrum München have pinpointed a major gene for allergic diseases. The gene was localized using cutting edge technologies for examining the whole human genome at the Helmholtz Zentrum München. The newly discovered FCER1A gene encodes the alpha chain of high affinity IgE receptor, which plays a major role in controlling allergic responses. The team of scientists led by Dr. Stephan Weidinger from the…

A simple and primitive animal, Trichoplax adhaerens, appears to harbor a far more complex suite of capabilities than meets the eye. The findings, reported Nature, establish a group of organisms as a branching point of animal evolution and identify sets of genes, or a "parts list," employed by organisms that have evolved along particular branches. Trichoplax adhaerens was first detected in the 1880s clinging to the sides of an aquarium but it just recently got characterized by the U.S. Department of Energy Joint Genome Institute (DOE JGI)and they found that its ancient lineage was matched by…

Trichoplax adhaerens is a bizarre little animal with a decidedly simple morphology. (You can see some here). There has been some question as to the relationship between this critter and other animal groups, but mitochondrial sequences (Dellaporta et al. 2006) and, as of this week, a complete nuclear genome sequence (Srivastava et al. 2008), suggest that it is a modern representative of the earliest branch to split from the rest of the animal lineages (for more detail, check out John Timmer's discussion). The term "basal" is usually applied to lineages like this, often with the assumption…

This appeared in my weekly automated journal search. I have ordered the paper as I can't find an online copy, but the abstract pretty much covers what the argument will be. Same old pre-1980s adaptationist idea presented as radically novel. Mallik, M. and Lakhotia, S.C. 2008. Noncoding DNA is not "junk" but a necessity for origin and evolution of biological complexity. Proceedings of the Indian National Science Academy Section B - Biological Sciences 77 (Sp. Iss.): 43-50. All eukaryotic genomes contain, besides the coding information for amino acids in different proteins, a significant…

A study of 228 women has revealed genetic variants responsible for body shape, according to research published in BMC Genetics. Based on work in the fruit fly Drosophila melanogaster, the study identifies natural variation in the human LAMA5 gene as a key determinant of weight. As the prevalence of obesity and related health problems continues to increase worldwide, there is considerable effort being devoted to identify genetic mechanisms that control fat storage. Maria De Luca led a team from the University of Alabama at Birmingham, USA, who identified candidate genes using different…