A First-Principles Model of Early Evolution
In their study,A first-principles model of early evolution: Emergence of gene families, species, and preferred protein folds, Shakhnovich et al present a new model of early biological evolution – the first that directly relates the fitness of a population of evolving model organisms to the properties of their proteins.
Key to understanding biological evolution is an important, but elusive, connection, known as the genotype-phenotype relationship, which translates the survival of entire organisms into microscopic selection for particular advantageous genes, or protein sequences. The study of…