Cancer Research

A new vaccine delivery system using microspheres of a biodegradable polymer may not only reduce the need for booster shots in some cases, but also appears to stimulate an immune response that traditional vaccines do not. Researchers from Iowa State University report their findings today at the ASM Biodefense and Emerging Disease Research Meeting. "Current vaccines are good at producing antibodies that block entry into the cell. In the case of some diseases, such as malaria or tuberculosis, antibody vaccines just aren't effective," says Jenny Wilson-Welder, a lead researcher on the study.…

On the Shangri-la diet forums, many dieters have reported better sleep. (”Woke up feeling like I could fight tigers. Have not felt this way since 2003. . . . I would stay on this method just for the sleep benefits,” wrote bekel.) To learn how widespread this was, I did a poll. Forty-two people answered. Two-thirds of them reported better sleep (half “much better” sleep, half “slightly better” sleep). Only one-tenth of them reported worse sleep (all “slightly worse”, none “much worse”). Almost all of them were doing SLD with oil, implying that the improvement was due to a few tablespoons of…

Purdue University researchers have created a handheld sensing system its creators liken to Star Trek's "tricorder" used to analyze the chemical components of alien worlds. But the system could have down-to-earth applications, such as testing foods for dangerous bacterial contaminants including salmonella, which was recently found in a popular brand of peanut butter. The new portable system is an ultrafast chemical-analysis tool that has numerous promising uses for detecting everything from cancer in the liver to explosives residues on luggage and "biomarkers" in urine that provide an early…

Deep red tomatoes get their rich color from lycopene, a disease-fighting antioxidant. A new study, however, suggests that a special variety of orange-colored tomatoes provide a different form of lycopene, one that our bodies may more readily use. Researchers found that eating spaghetti covered in sauce made from these orange tomatoes, called Tangerine tomatoes, caused a noticeable boost in this form of lycopene in participants' blood. "While red tomatoes contain far more lycopene than orange tomatoes, most of it is in a form that the body doesn't absorb well," said Steven Schwartz, the study…

MIT researchers have developed a technique to encourage the survival and growth of adult stem cells, a step that could help realize the therapeutic potential of such cells. Adult stem cells, found in many tissues in the body, are precursor cells for specific cell types. For example, stem cells found in the bone marrow develop into blood cells, bone cells and other connective tissues, and neural stem cells develop into brain tissue. Those stem cells hold great promise for treatment of injuries and some diseases, says MIT professor of biological engineering Linda Griffith. Griffith is the…

Mathematicians have finally laid to rest the legendary mystery surrounding an elusive group of numerical expressions known as the "mock theta functions." Number theorists have struggled to understand the functions ever since the great Indian mathematician Srinivasa Ramanujan first alluded to them in a letter written on his deathbed, in 1920. Now, using mathematical techniques that emerged well after Ramanujan's death, two number theorists at the University of Wisconsin-Madison have pieced together an explanatory framework that for the first time illustrates what mock theta functions are,…

Mayo Clinic researchers have safely transplanted cardiac preprogrammed embryonic stem cells into diseased hearts of mice successfully regenerating infarcted heart muscle without precipitating the growth of a cancerous tumor -- which, so far, has impeded successful translation into practice of embryonic stem cell research. The Mayo study is the first known report establishing a successful, tumor-resistant approach to growing new heart tissue from an embryonic stem cell source. The study is published in the February issue of the Journal of Experimental Medicine. Embryonic stem cells have the…

At any given time, most of the roughly 30,000 genes that constitute the human genome are inactive, or repressed, closed to the cellular machinery that transcribes genes into the proteins of the body. In an average cell, only about one in ten genes is active, or expressed, at any given moment, with its DNA open to the cell' transcriptional machinery. A dynamic cast of gatekeeper enzymes controls this access to the DNA, adding and removing particular molecules to open or close the genome to transcription as needed. Fully explicating the complex interplay among these enzymes and the molecules…

There is an urgent reason to study stem cells: stem cells are at the heart of some, if not all, cancers. Mounting evidence implicates a clutch of rogue stem cells brandishing ‘epigenetic’ marks as the main culprits in cancer. Wiping out tumours for good, some biologists believe, depends on uprooting these wayward stem cells. A team in the Netherlands has uncovered a key protein that could stop these stem cells from becoming malignant. “This is a hot topic in the cancer field,” Maarten van Lohuizen of The Netherlands Cancer Institute, Amsterdam told participants at a EuroSTELLS workshop,…

It's the most common bacteria-related sexually transmitted disease in the United States, so researchers at The University of Texas at San Antonio's South Texas Center for Emerging Infectious Diseases (STCEID) and The University of Texas at San Antonio Health Science Center have partnered to discover a vaccine that will prevent Chlamydia. According to the Centers for Disease Control and Prevention (CDC), Chlamydia is a common sexually transmitted disease caused by the bacterium, Chlamydia trachomatis, which can damage a woman's reproductive organs. In women, symptoms are usually mild or…