Cancer Research

Scientists have identified yet another risk from a high-salt diet. High concentrations of salt in the stomach appear to induce gene activity in the ulcer-causing bacterium Helicobacter pylori, making it more virulent and increasing the likelihood of an infected person developing a severe gastric disease. "Apparently the stomach pathogen H. pylori closely monitors the diets of those people whom it infects. Epidemiological evidence has long implied that there is a connection between H. pylori and the composition of the human diet. This is especially true for diets rich in salt," says Hanan…

The use of peginterferon alone, or in combination with ribavirin, points to a cure for hepatitis C, the leading cause of cirrhosis, liver cancer and the need for liver transplant, a Virginia Commonwealth University researcher said today. Mitchell Shiffman, M.D., professor in the VCU School of Medicine, and chief of hepatology and medical director of the Liver Transplant Program at the Virginia Commonwealth University Medical Center, is one of the lead investigators in the study, which was presented at the 38th annual Digestive Disease Week conference in Washington, D.C. VCU was among about…

Researchers at Harvard University and Princeton University have made a crucial step toward building biological computers, tiny implantable devices that can monitor the activities and characteristics of human cells. The information provided by these "molecular doctors," constructed entirely of DNA, RNA, and proteins, could eventually revolutionize medicine by directing therapies only to diseased cells or tissues. This work is a crucial step towards building biological computers, tiny implantable devices that can monitor the activities and characteristics of human cells. Courtesy Kobi Benenson…

Imagine if a naturally occurring chemical in your body could help make you feel more calm and relaxed – but it would only work during the long days of summer. The same chemical would, instead, make you aggressive and nasty when you were exposed to less daylight during the winter. That's exactly what occurs for a specific species of mouse, according to a new study at Ohio State University. Researchers found that the class of hormones called estrogens acts to increase aggression in the Oldfield Mouse (Peromyscus polionotus) during the short days of winter. However, when daylight increases in…

Peering into the body and visualizing its molecular secrets, once the stuff of science fiction, is one step closer to reality. The research team is reporting that by looking at images from radiology scans - such as the CT scans a cancer patient routinely gets - radiologists can discern most of the genetic activity of a tumor. Such information could lead to diagnosing and treating patients individually, based on the unique characteristics of their disease. "Potentially in the future one can use imaging to directly reveal multiple features of diseases that will make it much easier to carry out…

The use of targeted nanoparticles offers promising techniques for cancer treatment. Researchers in the laboratory of Mark E. Davis at the California Institute of Technology have been using small interfering RNA (siRNA), sometimes known as silencing RNA, to "silence" specific genes that are implicated in certain malignancies. One of the primary challenges associated with this type of therapy is delivering the therapeutic agent into the body and then to the tumor in a safe and effective manner. By using targeted nanoparticles, researchers have demonstrated that systemically delivered siRNA can…

A nanocomposite particle can be constructed so that it has a mix of properties that would not otherwise happen in nature. By combining an organic matrix with metallic clusters that can absorb light, it is possible to incorporate such particles into cells and then destroy those targeted cells with a laser. In a presentation at the NSTI Nanotech 2007 Conference, researchers describe work regarding the creation and characterization of a dendrimer nanocomposite (DNC) matrix containing silver clusters that can be used to target and destroy melanoma cancer cells. Composite NanoDevices (CNDs), are…

Northwestern University researchers have discovered that a recently identified genetic marker for prostate cancer is linked to a highly aggressive form of the disease. These findings ultimately will aid the development of a simple blood test to predict who is susceptible to this aggressive cancer, Northwestern researchers said. Knowing which patients carry this genetic marker also will guide doctors in how they treat the cancer. The Northwestern study showed a strong hereditary component to this aggressive cancer. Prostate cancer patients who carry the genetic marker – called 8q24 -- are…

By applying the techniques of computer engineering to a mechanistic diagram describing the development of the Nematode C. elegans, a group of researchers in Switzerland has been able to tease out what laboratory experiments have not – how and when the crucial cross-talk between cellular signaling pathways takes place in order to determine the fates of individual cells. During C. elegans development, uncommitted precursor cells differentiate into two distinct cell types in response to a series of complex biochemical signaling events. Cancer cells respond to the same cellular signals, so…

Tomatoes might be nutritious and tasty, but don’t count on them to prevent prostate cancer. In the May issue of Cancer Epidemiology, Biomarkers & Prevention, researchers based at the National Cancer Institute and Fred Hutchinson Cancer Research Center report that lycopene, an antioxidant predominately found in tomatoes, does not effectively prevent prostate cancer. In fact, the researchers noted an association between beta-carotene, an antioxidant related to lycopene, and an increased risk for aggressive prostate cancer. Not so fast, AP According to the researchers, the study is one of…