When Transcription Factors Go Rogue

All the cells in our body have the same set of genes.  The reason that we have arms, legs, heads, etc. is because transcription factors turn genes on and off in the right places at the right time.  This report out of Colorado Springs shows what happens when genes get turned on in the wrong place.  It appears that the poor child in this report was suffering from a teratoma:  an inappropriately placed but otherwise normal-looking  growth of a body structure in the form of a tumor.  Fortunately, the child is alive and hopefully will recover fully.

The placement of a fully formed foot inside this child's brain shows how developmental programs are hard-wired in our genome.  Once a cascade of transcription factors is triggered in a group of cells, it can autonomously create a full body structure such as a leg.  In this case, something inappropriately triggered the cascade in the wrong place.  Hopefully someday, we'll understand what causes things like this.  Then, we might actually be able to re-grow structures for other unfortunate people who need an organ replaced. 

I hope this kid is okay.

Old NID
35879

Latest reads

Article teaser image
Donald Trump does not have the power to rescind either constitutional amendments or federal laws by mere executive order, no matter how strongly he might wish otherwise. No president of the United…
Article teaser image
The Biden administration recently issued a new report showing causal links between alcohol and cancer, and it's about time. The link has been long-known, but alcohol carcinogenic properties have been…
Article teaser image
In British Iron Age society, land was inherited through the female line and husbands moved to live with the wife’s community. Strong women like Margaret Thatcher resulted.That was inferred due to DNA…