Women often gain weight as they age and a new study in Cell Metabolism says the sex hormone estrogen, and estrogen receptor-α (ERα) has an important yet under-appreciated role in those bigger waistlines.
Estrogen acts on receptors found throughout the body, in fat, on ovaries and in muscle. But when it comes to the hormone's influence on metabolism, the researchers suspected receptors in the brain. Others had traced the effects of estrogen on energy balance specifically to estrogen receptor-α (ERα) but when the team deleted those receptors from the entire brains of mice, "we got very, very fat mice," says Deborah Clegg of the University of Texas Southwestern Medical Center. The animals consumed more calories and burned less.
The findings may lead to the development of highly selective hormone replacement therapies that could be used to combat obesity or infertility in women without the risks for heart disease and breast cancer.
The researchers showed female mice lacking ERα in one part of the brain (the hypothalamic steroidogenic factor-1 or SF1 neurons) gained weight without eating any more. Loss of ERα from another brain area (the hypothalamic pro-opiomelanocortin or POMC neurons) had the opposite effect: animals ate more without gaining weight. Loss of ERα receptors in those same neurons also led to various problems in ovulation and fertility.
The findings suggest that drugs developed to specifically target estrogen receptors in the brain might offer a useful alternative to hormone replacement therapies that hit receptors throughout the body. The researchers say they would like to continue to isolate other estrogen-related effects and symptoms, for instance, on hot flashes and cognition.
"The more we know about estrogen's sites of action, the more likely it is we could develop designer hormone replacement therapies targeting tissue X, Y or Z,"Clegg said.
