Gene Linked To Cancer Suppression May Actually Promote Its Spread

A gene believed to suppress the growth and spread of cancer has the opposite effect in some forms of colorectal cancer, researchers have found. Sprouty2 is the gene and the new paper studied it in cancer cell models, mouse models and human biopsy samples. Using different molecular methods, the researchers found that the gene functions differently in colorectal cancer than in other types of cancers. Sprouty2 is known to block molecular circuits to prevent cancer cells from growing and spreading to other parts of the body. However, the researchers found that in colorectal cancer, Sprouty2 may increase the metastatic ability of cancer cells instead of suppress it. They believe this occurs when the gene is up-regulated, or supercharged.

A gene believed to suppress the growth and spread of cancer has the opposite effect in some forms of colorectal cancer, researchers have found.

Sprouty2 is the gene and the new paper studied it in cancer cell models, mouse models and human biopsy samples. Using different molecular methods, the researchers found that the gene functions differently in colorectal cancer than in other types of cancers. Sprouty2 is known to block molecular circuits to prevent cancer cells from growing and spreading to other parts of the body. However, the researchers found that in colorectal cancer, Sprouty2 may increase the metastatic ability of cancer cells instead of suppress it. They believe this occurs when the gene is up-regulated, or supercharged.

University of Missouri School of Medicine researcher Sharad Khare, Ph.D., found that a gene that is known to suppress the growth and spread of many types of cancer has the opposite effect in some forms of colorectal cancer. It is a finding that may lay the foundation for new colorectal cancer treatments. Credit: Justin Kelley/MU Health

Cancer deaths attributed to colorectal cancer are mainly due to tumor recurrence and metastasis to other organs. Excluding skin cancers, colorectal cancer is the third most common cancer diagnosed in both men and women in the United States, according to the American Cancer Society. It's estimated that the lifetime risk of developing colorectal cancer is about 1 in 20.

"The gene known as Sprouty2 has previously been shown to protect against metastasis, or the spreading of cancer to other parts of the body, in breast, prostate and liver cancer," said Sharad Khare, Ph.D., associate professor at
University of Missouri School of Medicine
and lead author of the study. "However, our recent molecular studies found that this gene may actually help promote metastasis instead of suppress it. This finding is a very significant step in our understanding of metastasis in colorectal cancer, but it's important to note that we believe this phenomenon may occur in only a subset of colorectal cancer patients. We don't yet know why this is the case, but we hope to determine if there is a correlation between the up-regulation of this gene and the life expectancy of patients with colorectal cancer. Future studies will help us understand who may be at risk, and ultimately, if personalized treatments can be planned to target this gene."

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