Life Sciences
The work of a Kansas State University professor is challenging the assumption that genetically engineered plants are the great scientific and technological revolution in agriculture and the only efficient and cheap way to feed a growing population.
Jianming Yu, an assistant professor of agronomy, is teaming with Rex Bernardo, a professor of agronomy and plant genetics at the University of Minnesota, on research with marker-assisted selection. This agricultural technology offers a sophisticated method to greatly accelerate classical breeding through genetic analysis and selection of existing…
Rheumatoid arthritis is a very common chronic illness that affects around 1% of people in developed countries. It is caused by an abnormal immune reaction to various tissues within the body. As well as affecting joints and causing an inflammatory arthritis, it can also affect many other organs of the body.
A paper published this week in the open access journal PLoS Medicine provides strong evidence that one specific part of the genome is associated with rheumatoid arthritis.
Rene Toes and colleagues from Leiden University Medical Center, the Karolinska Institute, and Celera studied four…
There are many changes in human physiology as the body adapts to zero gravity environments but a new study led by researchers from the Biodesign Institute at Arizona State University shows that the tiniest passengers flown in space — microbes — can be equally affected by space flight, making them more infectious pathogens.
“Space flight alters cellular and physiological responses in astronauts including the immune response,” said Cheryl Nickerson, who led a project aboard NASA’s space shuttle mission STS-115 (September 2006) involving a large, international collaboration between NASA, ASU and…
How do we choose our mates? Some scientists have suspected that it is not for looks or fashion or love but rather, genes.
A new study provides support for this idea by looking at lemurs in Madagaskar. Female fat-tailed dwarf lemurs (Cheirogaleus medius) live in life-long pairs, yet notoriously cheat on their partners to improve the genetic fitness of their offspring.
The team headed by Prof. Simone Sommer looked for possible genetic benefits in the obligate pair-living fat-tailed dwarf lemur which maintains life-long pair bonds but has an extremely high rate of extra-pair paternity.…
A paper published this week in the open access journal PLoS Medicine provides strong evidence that one specific part of the genome is associated with rheumatoid arthritis.
Rene Toes and colleagues from Leiden University Medical Center, the Karolinska Institute, and Celera studied four groups of patients and matched controls. They found a consistent association with one specific region of the genome -- a region on chromosome 9 that includes the two genes, complement component 5 (C5) of the complement system (a primitive system within the body that is involved in the defense against foreign…
Whether a smoking-cessation drug will enable you to quit smoking may depend on your genes, according to new genotyping research from the Centre for Addiction and Mental Health (CAMH). The study, published in the September issue of the journal Biological Psychiatry, found that the enzyme known to metabolize both the smoking cessation drug bupropion and nicotine is highly genetically variable in all ethnicities and influences smoking cessation. This finding is a step toward being able to tailor smoking cessation treatment to individuals based on their unique genetic make-up.
“This first study…
Women and men appear to respond differently to the same biochemical manipulation. Major depressive disorder (MDD) is one of the most common mental disorders, and it is also one of the most studied. It is already known that reduced serotonin transmission contributes to the pathophysiology, or functional changes, associated with MDD and most of today’s most popular antidepressants block the serotonin “uptake site”, also known as the transporter, in the brain. It is also known that people with MDD are frequently found to have impaired impulse control.
A new study being published in the…
A new study published in Nature Genetics on Sunday 16 September 2007 show that common, complex diseases are more likely to be due to genetic variation in regions that control activity of genes, rather than in the regions that specify the protein code.
This surprising result comes from a study at the Wellcome Trust Sanger Institute of the activity of almost 14,000 genes in 270 DNA samples collected for the HapMap Project. The authors looked at 2.2 million DNA sequence variants (SNPs) to determine which affected gene activity.
They found that activity of more than 1300 genes was affected by DNA…
Using atom-level imaging techniques, University of Michigan researchers have revealed important structural details of an enzyme system known as "Mother Nature's blowtorch" for its role in helping the body efficiently break down many drugs and toxins.
The research has been detailed in a series of papers, the most recent published online this month in the journal BBA Biomembranes.
The system involves two proteins that work cooperatively. The first, cytochrome P450, does the actual work, but only when it gets a boost from the second protein, cytochrome b5. To complicate matters, the two proteins…
Many neuronal disorders, including epilepsy, schizophrenia and lissencephaly – a form of mental retardation -, result from abnormal migration of nerve cells during the development of the brain. Researchers from the Mouse Biology Unit of the European Molecular Biology Laboratory (EMBL) in Italy, have now discovered that a protein that helps organising the cells’ skeleton is crucial for preventing such defects.
In the current issue of Genes & Development they report that mice lacking the protein show symptoms of lissencephaly brought about by faulty development of the cerebral cortex, the…