Stress 'Unravels' Brain Structure - Study
The helpless behavior that is commonly linked to depression and post-traumatic stress disorder (PTSD) is preceded by stress-related losses of synapses—microscopic connections between brain cells—in the brain’s hippocampal region, researchers at Yale School of Medicine report in Biological Psychiatry. The team used a six-day treatment with the antidepressant desipramine to reverse helpless behavior and restore hippocampal synapses in rats. “In clinical practice, the main problem with antidepressants is that they require weeks to exert their effect,” said lead scientist on…