Protein S, a well-known anticoagulant protein, also contributes to the formation and function of healthy blood vessels, say researchers at the Salk Institute for Biological Studies. They found that mice lacking protein S suffered massive blood clots, but also had defective blood vessels that allow blood cells to leak into the surrounding tissue.
There are more than 200 known human mutations and polymorphisms in the gene coding for protein S, which was arbitrarily named after Seattle, the city of its discovery. The resulting deficiencies predispose carriers to deep venous thrombosis,…