Dr.Varaprasad Bobbarala M.Sc., Ph.D.

Chief Scientist,

Translational Research Institute of Molecular Sciences (TRIMS)
Skype: varaprasadbobbarala
Mobile : 9949129539
PROFILE
                Expertise in the area of new drug discovery and development, in vitro&in vivo
efficacy studies, Cell based assays, Antioxidant studies and Analytical
chemistry. Management of projects and Involved actively in Drug
Discovery Research for over 4 years, leading a team of researchers
dedicated to the isolation, identification, bioassays and preclinical
development of novel therapeutic leads from natural products.
STRENGTHS
1. Planning, Implementation and Management of Drug Discovery Research Projects.
2. Design and Development of Biochemical/Pharmacological (in vitro and in vivo) Assays/Test Models for Drug Discovery.
3. Management of Resources and Time.
4. Extensive Experience in Phytochemistry, Biotechnology, Microbiology, Biochemistry and Analytical chemistry.
5. Experience in Setting up Facility for Drug Discovery Research and Bio assays.
PROFESSIONAL EXPERIENCE
Current Position:
Chief Scientist                                                                                     2011-Till date      
                Translational Research Institute of Molecular Sciences (TRIMS) 
                Visakhapatnam, Andhrapradesh.
 Past Positions:
 Chief Scientist (Research&Development)                                 2010-2011           
                Vivimed Labs Limited (Nisarg), Hyderabad, Andhrapradesh.
                Projects Completed at Vivimed Labs Ltd.
Docosahexaenoic acid (DHA):
                Production, extraction, purification and Isolation of Docosahexaenoic acid from Marine algal source using fermentation method.
Skin Whitening Project:
               
Isolation of active marker compounds from medicinal plants and their
formulation for skin whitening properties with bioassay claims
Anti-Ageing Project:
                Identification, isolation and formulation of active ingredients from natural sources and development of anti-ageing product
Anti-Stretch mark Project:
                Isolation
of claimed marker compound from selected medicinal plant and
development of product along with cell based bioassay support.
Oral Care Project:
                Screening
of 75 traditional medicinal plants for antimicrobial properties and
bioassay guided fractionation of active metabolites from highly active
medicinal plants and isolation, formulation and product development.
Scientist In-Charge,                                                                                           2007 –Feb, 2010  
                For 'U' Biosciences, Visakhapatnam, Andhrapradesh,
                                Overall monitoring of research and development activities.      
                Biochemist,                                                                                                          2002 –Dec, 2003
                Vimta Labs Limited, Hyderabad- Visakhapatnam, Andhrapradesh.  
                Analysis of Bio-Molecules, Clinical Bio-Chemistry, Molecular Biology and Micro-Biology.
MEMBERSHIP IN PROFESSIONAL BODIES
1)                  European Biotechnology Network (ID: MP334772)
2)                  Indian Science Congress Association (Membership ID: A683)
EDITORIAL BOARD MEMBER
1)                  Journal of Pharmacy Research (JPR)
2)                  International Journal of Contemporary Research and Review (IJCRR)
3)                  Pharmacophore (An International Research Journal)
4)                  Drug Invention Today (DIT)
5)                  International Journal of Chemical and Analytical Science (IJCAS)
6)                  Regional Editor (Scientia Publications)
7)                  Research in Pharmaceutical Biotechnology (Academic Journals)
8)                  Indian Journal of Novel Drug Delivery (IJNDD)
PEER REVIEWER FOR JOURNALS
1)                  Indian Journal of Science and Technology (IJST)
2)                  Research in Pharmaceutical Biotechnology (RPB)
3)                  International Journal of Contemporary Research and Review (IJCRR)
4)                  Journal of Pharmacy Research (JPR)
5)                  Indian Journal of Microbiology (INJM)
6)                  African Journal of Biotechnology (AJB)
7)                  African Journal of Traditional, Complementary and Alternative medicines (AJTCAM)
EDUCATION
Ph.D., Natural Product Chemistry, Andhra University, Nov 2008.
Mentor     : Professor. K. Chandrasekhar Naidu  
Thesis Title    : A Search for Antimicrobial Agents from Plant Resources to control Sorghum and Pennisetum Pathogens and Phytochemical Investigation of Scoparia dulcis L.
WORKSHOPS/TRAINING ATTENDED
1)                  Participated in National workshop on Recent Developments In Microbiology organized by UGC, CSIR and A.P. State Council of higher education, Department of Microbiology, Andhra University (Oct 18th -20th, 08).
2)                  Participated in National Workshop on Bioinformatics organized by UGC-SAP, Department of Botany, Andhra University (Jan 24th -29th, 05).

MANUSCRIPTS PUBLISHED/ACCEPTED IN PEER REVIEWED JOURNALS
1.                 
A novel high resolution RP-UPLC method for the quantitative
determination of exemestane and its related compounds, Journal of Pharmacy Research 2011, 4(2), 546-548. Maheswara Reddy Musirike, K. Hussain Reddy, Ramkumar Dhandapani, Useni Reddy Mallu and Varaprasad Bobbarala.
2.                  Development of new Reverse phase -HPLC method for analysis and assay of Zopiclone in Formulation, Journal of Pharmacy Research 2011, 4(1), 248-249. MV. Basaveswara Rao, AVD. Nagendrakumar, M. Sivanadh, PV. Bramhachari, VaraprasadBobbarala.
3.                  Evaluation of Hydroxyl radical scavenging activity and HPTLC fingerprint profiling of Aegle marmelos (L.) Correa extracts, Journal of Pharmacy Research 2011, 4(1), 252-255. P V.Bramhachari, J. Ravichand, YHK Reddy, D. Kotresha, K. Viswanatha Chaitanya and Varaprasad Bobbarala.
4.                  In vitro Antibacterial Screening of Five Local Medicinal Plants of Araku Environment, Drug Invention Today 2011, 3(3), 14-15. Sunilbabu Koppula, K. Ammani, Varaprasad Bobbarala and Y. Usha.
5.                  Antibacterial activity screening of few medicinal plants from the Southern Region of India, Journal of Pharmacy Research, 2010, 3(10), 2453-2456. Sunilbabu Koppula, K. Ammani, Varaprasad Bobbarala and P. V. Bramhachari.
6.                  Inhibition of plant pathogenic fungi by ethnobotanically selected plant extracts, Journal of Pharmacy Research, 2010; 3(9): 2334-2336. Sunilbabu Koppula, K. Ammani, Varaprasad Bobbarala and P. V. Bramhachari.
7.                  Antibacterial Efficacy of Secondary Metabolites from Entomopathogenic Fungi Beauveria bassiana, International Journal of Chemical and Analytical Science, 2010; 1(5): 855-856. Narasimha Reddy Parine, Akbar Ali Khan Pathan, Sarayu B, Veeturi Sudha Nishanth, Varaprasad Bobbarala.
8.                  Tannin acyl hydrolase from Trichoderma viride, International Journal of Chemical and Analytical Science, 2010; 1(5): 106-109. N. Lokeswari, K. Jaya Raju, Sudhakar Pola and Varaprasad Bobbarala.
9.                  Production of 3, 4, 5- trihydroxybenzoic acid by solid-state fermentation, Journal of Pharmacy Research, 2010; 3(5): 1131-1133. N. Lokeswari, D. Sriramireddy, Sudhakar Pola and Varaprasad Bobbarala.
10.             
Pollution monitoring of coastal and estuarine areas: Bacterial
indicators along Champavathi Estuary, Vizianagaram, East coast of India, Journal of Pharmacy Research, 2010; 3(5): 1158-1159. M. Sridevi, B. Kondala Rao, Varaprasad Bobbarala.
11.              Production of an antibacterial drug trimethoprim using novel biotechnological approach, Drug Invention Today, 2010, 2(5), 268-270. N. Lokeswari, D. Sriramireddy, Sudhakar Pola and Varaprasad Bobbarala.
12.              Extraction of tannins from Anacardium occidentale and effect of physical parameters, Journal of Pharmacy Research, 2010; 3(4): 906-908. N. Lokeswari1, D. Sriramireddy, Sudhakar Pola and Varaprasad Bobbarala.
13.              Antifungal Efficacy of Secondary Metabolites from Entomopathogenic Fungi Beauveria bassiana, Journal of Pharmacy Research, 2010; 3(4): 855-856. Narasimha Reddy Parine, Devinder Kumar, Akbar Ali Khan P, Varaprasad Bobbarala.
14.              RP-HPLC method development and validation for determination of dissolution and assay of sildenafil citrate tablets, Journal of Pharmacy Research, 2010; 3(3): 631-635. Useni Reddy Mallu K. Hussain Reddy, Varaprasad Bobbarala and Somasekhar Penumajji.
15.              Method
Development of stability indicating HPLC method for the determination
of Amiodarone Hydrochloride in pharmaceutical dosage form, Drug Invention Today, 2010; 2(2): 160-162. Useni Reddy Mallu K. Hussain Reddy, Varaprasad Bobbarala and Somasekhar Penumajji.
16.              HPLC Method Development for Glucosamine Sulphate and Diacerein Formulation, Journal of Pharmacy Research, 2010; 3(2): 361-363. Useni Reddy Mallu K. Hussain Reddy, Varaprasad Bobbarala and Somasekhar Penumajji.
17.              Bio-efficacy of selected medicinal plants against phytopathogens of cereal crops and phytochemical examination of Prosopis juliflora (sw) dc. Journal of Pharmacy Research, 2010; 3(2): 356-360. B. Seetha Lakshmi, K. C. Naidu, Y.L.N.Murthy, Varaprasad Bobbarala, N. Pandit.
18.              RP-HPLC method development for the determination of assay of Donepezil hydrochloride, International Journal of Chemical and Analytical Science, 2010; 1(2): 35-36.. Useni Reddy Mallu K. Hussain Reddy, Varaprasad Bobbarala and Somasekhar Penumajji.
19.             
Extraction and optimization of molecular marker compounds from
Asparagus racemosus using HPLC with ELS detector, Journal of Pharmacy Research, 2010; 3(1): 159-162. Somasekhar Penumajji, Varaprasad Bobbarala and K. Chandrasekhar Naidu.
20.              Chemical and biological examination of the leaves of Tephrosia tinctoria PERS. International Journal of Chemical and Analytical Science, 2010; 1(1): 14-17. P. Lakshmi, Varaprasad Bobbarala, S. Ganapaty.
21.              In Vitro Screening of Nine Indian Medicinal Plant Species against Selected Clinical Pathogens. Journal of Pharmacy Research, 2010; 3(1): 166-168. Sunilbabu Koppula, K. Ammani and Varaprasad Bobbarala.
22.              In Vitro Free Radical Scavenging Activity Of Sorghum Bicolor (L.) Moench. Drug Invention Today, 2010; 2(1): 13-16. Vijaya, N. Sarada mani and Varaprasad Bobbarala.
23.             
Comparison of Evaporative Light Scattering Detector with UV Detection
System in the Molecular Marker Compounds Analysis of Asparagus Racemosus. Journal of Global Pharma Technology; 2010: 1(1). Somasekhar Penumajji, Varaprasad Bobbarala.
24.              Bactericidal activities of different Medicinal plants extracts against Ocular pathogen viz Corynebacterium macginleyi. Drug Invention Today, 2010; 2(1): 5-7. Nagendra Kumar Koday, G. Subba Rangaiah, Varaprasad Bobbarala, Sirisha Cherukuri.
25.              Anti-bacterial properties of herbal extracts towards bacterial pathogens in poultry. Journal of Pharmacy Research, 2009; 2(12): 1883-1884. Varaprasad Bobbarala, Vinila Duggirala and Esteru rani G.
26.             
Bioequivalence Study of Formulation Rabiplus-XT with Reference Rabium
Plus after Single Dose Administration in Healthy Volunteers. Drug Invention Today, 2009; 1(1): 13-15. Somasekhar Penumajji, Varaprasad Bobbarala, K. Chandrasekhar Naidu.
27.              Enhancement of Protein Hydrolysates Production by Using Doehlert-Design Approach. Journal of Pharmacy Research, 2009; 2(12): 1889-1892. T. Sathish, K. Prasanth Kumar, B.B.Teja, Varaprasad Bobbarala, R.S.Prakasham, Somasekhar Penumajji.
28.              In vitro Control of some Ocular infectious bacteria by using medicinal plants Adhatoda vasica, Cassia occidentalis and Phyllanthus amarus. Journal of Pharmacy Research, 2009; 2(12): 1869-1872. Nagendra Kumar Koday, G. Subba Rangaiah, Varaprasad Bobbrala, Sirisha Cherukuri and Vinila Duggirala.
29.              Control of phytopathogenic fungi Colletotrichum graminicola using medicinal plant methanolic extracts. Drug Invention Today, 2009; 1(1): 3-6. Varaprasad Bobbarala, Prasanthkumar Katikala, Vinila Duggirala, Somasekhar Penumajji.
30.              Vitexagnus castus molecular marker compounds extraction and optimization using HPLC with ELS detector. Drug Invention Today, 2009; 1(1): 39-45. Somasekhar Penumajji, Varaprasad Bobbarala, K. Chandrasekhar Naidu.
31.              A Randomised Bioequivalence Study on Vigrex in Twelve Healthy Human Subjects under Fasting Conditions. Journal of Pharmacy Research, 2009; 2(11): 1751-1753. Somasekhar Penumajji, Varaprasad Bobbarala, Rajesh Kumar Chadaram, K. Chandrasekhar Naidu.
32.              Excoecaria agallocha L. Antimicrobial Properties against Important Pathogenic Microorganisms. International Journal of Chem Tech Research, 2009; 1(4): 865-867. Varahala Rao Vadlapudi, Varaprasad Bobbarala, Somasekhar Penumajji, K. Chandrasekhar Naidu.
33.              Antimicrobial Agents from Rubia Cordifolia And Glycyrrhiza Glabra Against Phytopathogens Of Gossypium, International Journal of Chem Tech Research, 2009; 1(4): 1512-1518, K. C. Naidu, Ramya Lalam and Varaprasad Bobbarala.
34.              Screening of L-glutaminase Producing Marine Bacterial Cultures for Extracellular Production of L-glutaminase.  International Journal of ChemTech Research, 2009; 1(4): 1232-1235. Prasanth Kumar Katikala, Prabhakar Tadimalla, Varaprasad Bobbarala, Girija Sankar Guntuku.
35.              Abrus Precatorius L. Seed Extracts against Clinically Important Bacteria. International Journal of Pharm Tech Research, 2009; 1(4): 1115-1118.  Varaprasad Bobbarala and Varahala Rao Vadlapudi.
36.              Antioxidant and Free Radical Scavenging Activity of Sorghum bicolor (L.) Moench. Journal of Pharmacy Research, 2009; 2(10): 1659-1662. T. Bangaru Naidu, S. Nageswara Rao, N. Sarada Mani, Varaprasad Bobbarala.
37.              Mutagenicity Study of Butyl Methoxy Dibenzoylmethane by Using Salmonella typhimurium. Journal of Pharmacy Research, 2009; 2(9): 1540-1541. Somasekhar Penumajji, Varaprasad Bobbarala, K. Chandrasekhar Naidu.
38.              Biocide Potentialities of Different Plant Methanolic Extracts against Crown Gall Bacteria viz Agrobacterium tumefaciens. Biomedical and Pharmacology Journal, 2009; 02(01): 79-84. Varaprasad Bobbarala, G. Srinivasa Rao, D. Bindu Madhuri, K. Chandrasekhar Naidu.
39.              Bactericidal Activities of Fifty Medicinal Plants Methanolic Extracts against Pseudomonas syringae pv. Syringae. Biomedical and Pharmacology Journal, 2009; 2(1): 61-66. Varaprasad Bobbarala, G. Srinivasa rao, D. Aryamithra, K. Chandrasekhar Naidu and G. Seshagiri Rao.
40.              Medicinal plants as alternatives for the management of Pennisetum diseases. International journal of Crop Research, 2009; 38(3): 392-397. Varaprasad Bobbarala, D. Bindu maduri and D. Aryamithra.
41.              A Case Study Of Sexual Assault By DNA Finger Printing Technology Using PCR Based STR Analysis. Journal of Pharmacy Research, 2009; 2(6): 1079-1082. Somasekhar Penumajji, Varaprasad Bobbarala and K. Chandrasekhar Naidu.
42.              Biological Control of Phytopathogenic Bacteria Pantoea agglomerans Using Medicinal Plant Extracts. International Journal of Pharmagenesis, 2010; 1(1): 113-117. Varaprasad Bobbarala, Varahalarao Vadlapudi, K. Chandrasekhar Naidu, Somasekhar Penumajji.
43.              In Vitro Antimicrobial Activity of Two Mangrove plants Aegiceras corniculatum and Hibiscus tiliaceous. Journal of Biosciences Biotechnology Research Asia, 2009; 06 (1): 321-324. Varahala Rao Vadlapudi and Varaprasad Bobbarala.
44.              Comparative Screening of Selected Mangrove Plant Methanolic Extracts against Clinical and Plant Pathogens. Journal of Pharmacy Research, 2009; 2 (6): 1062-1064. Varahala Rao Vadlapudi, Varaprasad Bobbarala and K. Chandrasekhar Naidu.
45.              Antimicrobial Potentialities of Mangrove Plant Avicennia marina. Journal of Pharmacy Research, 2009; 2(6): 1019-1021. Varaprasad Bobbarala, Varahala Rao Vadlapudi, K. Chandrasekhar Naidu.
46.              Medicinal Plants as Alternative Bio-control Agents in The Control of Seed Borne Pathogen Macrophomina phaseolina. Journal of Pharmacy Research, 2009; 2 (6): 1045-1048. Varaprasad Bobbarala, Rajesh Kumar Chadaram, Varahalarao Vadlapudi and Prasanth Kumar Katikala.
47.              In Vitro Antimicrobial Properties of Mangrove Plant Thespesia populneoides against Selected Clinical, Plant and Aquatic Pathogens. Journal of Biosciences Biotechnology Research Asia, 2009; 6(1): 351-354. Varaprasad Bobbarala, Varahala Rao Vadlapudi and K. Chandrasekhar Naidu.
48.              In Vitro Antimicrobial Screening of Mangrove Plant Avicennia officinalis. Oriental Journal of Chemistry, 2009; 25(2): 373-376. Varaprasad Bobbarala, Varahalarao Vadlapudi, K. Chendrashekar Naidu.
49.              Mangrove Plant Sonneratia apetala Antimicrobial Activity on Selected Pathogenic Microorganisms. Oriental Journal of Chemistry, 2009; 25(2): 445-447. Varaprasad Bobbarala, Varahalarao Vadlapudi, K Chendrashekar Naidu.
50.              Bio activity of Psoralea corylifolia l. Seeds against selected plant and clinical pathogens. Asian J. Exp. Sci., 2009; 23(3): 503-506.  Varaprasad Bobbarala, V. Varahala Rao, G. Srinivasa Rao, and D. Bindu Maduri.
51.              A Search for Alternatives to Control Phytopathogenic Fungi Curvularia Lunata. Asian J. Exp. Sci., 2009; 23(3): 445-450. Varaprasad Bobbarala, K. Chandrasekhar Naidu.
52.              Antifungal Activity of Selected Plant Extracts against Phytopathogenic Fungi Aspergillus niger F2723. Indian Journal of Science and Technology, 2009; 2(4): 87-90. Varaprasad Bobbarala, Prasanth Kumar Katikala, K. Chandrasekhar Naidu, Somasekhar Penumajji.
53.              Antimicrobial Screening of Asparagus recemosus on Aquatic, Plant and Human Pathogens. Journal of Pure&Applied Microbiology, 2009; 03(01): 235-238. Varaprasad Bobbarala, G. Srinivasa Rao, D. Bindu Maduri, and D. Aryamithra.
54.              In vitro antimicrobial activity of certain medicinal plant extracts against pathogens of Sorghum. Journal of Pure&Applied Microbiology, 2009; 03(01): 205-209. Varaprasad Bobbarala and D. Bindu Maduri.
55.              Bioactivity of Andrographis paniculata against selected phytopathogens. Journal of Pharmacy Research, 2009; 2(3): 480-482. Varaprasad Bobbarala, P. Koteswara Rao, G. Srinivasa Rao and D. Aryamithra.
56.              Total antioxidant power and free radical scavenging capacity of some medicinal plants. Journal of Biosciences, Biotechnology Research Asia, 2009; 05(2): 837-840. P. Koteswara Rao, Varaprasad Bobbarala, D. Bhaskar Rao, Ch. Ravi Kiran, K.V. Raghava Rao and T. Raghava Rao.
57.              In vitro antibacterial activities of plant essential oils against oral bacteria. Ind. J. Multi. Res., 2008; 4(4): 507-516. P. Koteswara Rao, Varaprasad Bobbarala, D. Aryamithra, P. Subhashini Devi and T. Raghava Rao.
58.              Optimization of Xylanase production under solid state fermentation by isolated Aspergillus fumigatus (MTCC 9372). Ind. J. Multi. Res., 2008; 4(4): 517-528. Nagamalleswararao Beeraka, Prasanth Kumar Katikala, Varaprasad Bobbarala, Prabhakar Tadimalla.
59.              Antimicrobial screening of Acacia farnesiana (L.) WILLD. Ind. J. Bot. Res., 2008; 4(2): 249 -251. Thirupal Reddy B, Varaprasad Bobbarala and D. Ali Moulali.
MANUSCRIPTS PRESENTED AT INTERNATIONAL/NATIONAL LEVEL
60.              An Alternative Approach to Control Aeromonas hydrophila Using Important Herbal Extracts. 97th Indian Science Congress held at Thiruvananthapuram, Varaprasad Bobbarala, D. Bindu Madhuri, D. Aryamithra and K. Chandrasekhara Naidu.
61.              In Vitro
Bio Control Of Phytopathogenic Bacteria Using Medicinal Plants.
National symposium on Emerging Trends In cell and Nano Biotechnology
held at Department of Biotechnology, GITAM University, Visakhapatnam on
11th to 12th December 2009, Varaprasad Bobbarala, D. Bindu Maduri, D. Aryamithra. 
62.             
Presented a paper in State level seminar on EMERGING TRENDS IN
AQUACULTURE organized by UGC, Co-Sponsored by DST and Govt. of India,
Department of Zoology, D N R College,  Bhimavaram (Sept 5th -6th, 09).
63.             
Presented a paper in State level seminar on Biotechnologies&
Developmental Strategies for Eco restoration of Mangrove Forests of
Andhrapradesh organized by P.G. Departments of Botany and Biotechnology,
Dr. V. S. Krishna Govt. College, Visakhapatnam on 22nd and 23rd March, 2008.
64.              In Vitro Antimicrobial Activity of Two Mangrove plants Aegiceras corniculatum and Hibiscus tiliaceous. Poster presented at International conference Bangalore Bio 2009, June 18-20, 2009, Varaprasad Bobbarala, Varahalarao Vadlapudi, D. Bindu Madhuri and D. Aryamithra.
65.             
A Search for New Alternatives in the Treatment of Oral Diseases Using
Indian Traditional Medicinal Plants. Poster presented at International
conference Bangalore Bio 2009, June 18-20, 2009, Koteswara Rao. P and Varaprasad Bobbarala. 
66.              In vitro antimicrobial activity of certain medicinal plant extracts against pathogens of Sorghum
In a special volume published as proceedings of National symposium on
Trends in Plant Science Research held at Department of Botany, Andhra
University, Visakhapatnam on 8th to 10th December 2006, pp. 26. Varaprasad Bobbarala, K. C. Naidu, G. Seshagiri Rao.
67.              Antimicrobial studies of Catunaregam spinosa
(Thunb) Thirv (Rubiaceae) In a special volume published as proceedings
of National symposium on Trends In Plant Science Research held at
Department of Botany, Andhra University, Visakhapatnam on 8th to 10th  December 2006, pp. 28. B. Thirupal Reddy, B. Varaprasad and, D. Ali Moulali.
MANUSCRIPTS PUBLISHED IN REFERRED BOOKS
68.              An alternative approach to control Aeromonas Hydrophila
using important herbal extracts in the book of Bioresources for Rural
Livelihood, Vol. I. Genetics, Biochemistry and Toxicology. Varaprasad Bobbarala, D. Bindu Madhuri, D. Aryamithra and K. Chandrasekhara Naidu.
69.              Antimicrobial studies of Catunaregam spinosa
(Thunb) Thirv (Rubiaceae) in the book of Genome Characterization:
Basics and applications. B. Thirupal Reddy, B. Varaprasad and D. Ali
Moulali.
70.              In vitro antimicrobial activity of certain medicinal plant extracts for Sorghum diseases in the book of Genome Characterization: Basics and applications. Varaprasad Bobbarala and K. C. Naidu.

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