Mainly two types of RNA viz coding RNA and non-coding RNA were recognised. Although 90 percent of the genome is transcribed but only a small fraction i.e. 1.5 percent transcribed RNA is used for coding the protein sequence as mRNA.
The major portion of non-coding RNA ( which mainly comprised of rRNA, tRNA , mi RNA, si RNA, snoRNA and snRNA) ) has been assigned several functions in disease development including their role in cancer development.
Around 88.5 percent of the RNA transcripts are the source of noncoding RNA having regulatory functions.
Around 450,000 ncRNA are genes are coded. Many nc RNA like ribosomal RNA (r RNA) or micro-RNA(miRNA) play important role in physiological processes and perhaps in disease development including cancer. Investigations on such mi RNA sequences and establishing their role in disease developmet could lead to finding solutions in the direction of control of diseases including (possibly ) cure for cancer.
The role of ncRNA in disease development has been well documented by Rederstoff M and Huttenhofer, A (2010) in recent review published in Current openion in molecular therapeutics.
Mainly two types of RNA viz coding RNA and non-coding RNA were recognised. Although 90 percent of the genome is transcribed but only a small fraction i.e. 1.5 percent transcribed RNA is used for coding the protein sequence as mRNA.
The major portion of non-coding RNA ( which mainly comprised of rRNA, tRNA , mi RNA, si RNA, snoRNA and snRNA) ) has been assigned several functions in disease development including their role in cancer development.
Around 88.5 percent of the RNA transcripts are the source of noncoding RNA having regulatory functions.
