c.280 Pappus, an Egyptian mathematician, compiled a summary of all mathematical knowledge to date (list)

c.300 In Bernares, Vatsayana Mallagana publishes the Kama Sutra, a comprehensive guide to sexual etiquete.

c. 310 Diophantus of Alexandria outlined the elements of algebra, including the composition of formulas and the substitution of letters for unknown quantaties.

Meanwhile, the Huns, originally from Siberia, invaded Europe 375

c. 500 India, Aryabhata demonstrates the use of negative numbers and trigonometry. 

c.520 Indian mathematicians adopt the decimal system.