Induced pluripotent stem cell (iPSC) research in the last 2 years has faced many twists and turns. With scientists uncovering a number of disturbing genomic abnormalities in these cells, the future of iPSC technology looked like a sea of despair.

But lucky for those who persisted in this field of research, recent findings based on deep genome sequencing data revealed that these so-called "genomic abnormalities" simply reflect the normal genomic quirks of the original somatic cells from which iPSCs were derived. 

References:
Cheng et al, 2012 (Cell Stem Cell 10, 337–344)Young et al 2012 (Cell Stem Cell 10, 1-13)

Old NID
90852

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