Using living cells as more efficient tools for delivering medicines to diseased parts of the body has gotten a little closer.
In a new report, Dayang Wang and colleagues explain that the human body's efficiency in getting rid of foreign substances can also be an obstacle. Some foreign substances, such as viruses, are harmful and should obviously be removed, but the body also considers drugs and nanoparticles — meant to treat diseases and allow physicians to see cells and organs — to be foreign objects, and they are also quickly removed.
To help these substances stay in the body longer, scientists have tried to fool it by encapsulating these substances in coatings that more closely resemble natural cells. Over the years, researchers have tested many different artificial coatings, but they failed to stay in the body for very long. So, Wang and colleagues set out to make a better capsule, by using living cells as an "invisibility cloak".
Because the group's so-called "cell membrane capsules" (CMCs) were made from real living cells, they tricked the body into thinking they were supposed to be there. Thus, drugs and nanoparticles inside CMCs stayed in the body much longer than those inside other encapsulation materials.
"Hence the CMCs provide the first intrinsically biocompatible and functional drug delivery and release vehicles," say the researchers.
- Nano Letters
